2024
de Melo Espirito Santo, Caique; Santos, Verônica S.; Kamper, Steven J.; Williams, Christopher M.; Miyamoto, Gisela C.; Yamato, Tiê P.
Overview of the economic burden of musculoskeletal pain in children and adolescents: a systematic review with meta-analysis Journal Article
In: PAIN, vol. 165, no. 2, pp. 296–323, 2024, ISSN: 1872-6623.
Abstract | Links | BibTeX | Tags: Anesthesiology and Pain Medicine, Neurology, Neurology (clinical), Pain
@article{EspiritoSanto2023,
title = {Overview of the economic burden of musculoskeletal pain in children and adolescents: a systematic review with meta-analysis},
author = {Caique de Melo Espirito Santo and Verônica S. Santos and Steven J. Kamper and Christopher M. Williams and Gisela C. Miyamoto and Tiê P. Yamato},
url = {https://painsmart-education.sydney.edu.au/wp-content/uploads/2024/03/Overview-of-the-economic-burden-of-musculoskeletal_a-systematic-review-with-meta-analysis.pdf, PDF},
doi = {10.1097/j.pain.0000000000003037},
issn = {1872-6623},
year = {2024},
date = {2024-00-00},
urldate = {2024-00-00},
journal = {PAIN},
volume = {165},
number = {2},
pages = {296--323},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
abstract = {<jats:title>Abstract</jats:title>
<jats:p>Studies suggest a high economic burden among children and adolescents with musculoskeletal pain. There is no summary in the literature on the overall economic burden of musculoskeletal pain in children and adolescents. The aim of this systematic review of cost-of-illness studies was to synthesize the economic burden of musculoskeletal pain in children and adolescents. We conducted electronic searches on MEDLINE, EMBASE, CINAHL, EconLit, NHSEED, and HTA databases. We included cost-of-illness studies that estimated healthcare, patient/family, lost productivity, and/or societal costs in children and adolescents with musculoskeletal pain. The risk of bias was assessed with the Consolidated Health Economic Evaluation Reporting Standards checklist. All values were adjusted to the same reference year (2021) and converted to American Dollar. We included 45 cost-of-illness studies (n = 665,623). Twenty-two studies estimated the annual healthcare costs that ranged from $143 to $41,379 per patient. Nine studies estimated the annual patient/family costs that ranged from $287 to $27,972 per patient. Seven studies estimated the annual lost productivity costs that ranged from $124 to $4671 per patient. Nine studies estimated the annual societal costs that ranged from $1095 to $69,351 per patient. Children and adolescents with juvenile idiopathic arthritis and musculoskeletal pain had higher annual incremental healthcare costs than those without these conditions (mean difference: $3800 higher, 95% confidence interval [CI]: 50-7550; mean difference: $740 higher, 95% CI: 470-1,010, respectively). In conclusion, the estimated annual economic burden of children and adolescents with musculoskeletal pain ranged from $124 to $69,351.</jats:p>},
keywords = {Anesthesiology and Pain Medicine, Neurology, Neurology (clinical), Pain},
pubstate = {published},
tppubtype = {article}
}
<jats:p>Studies suggest a high economic burden among children and adolescents with musculoskeletal pain. There is no summary in the literature on the overall economic burden of musculoskeletal pain in children and adolescents. The aim of this systematic review of cost-of-illness studies was to synthesize the economic burden of musculoskeletal pain in children and adolescents. We conducted electronic searches on MEDLINE, EMBASE, CINAHL, EconLit, NHSEED, and HTA databases. We included cost-of-illness studies that estimated healthcare, patient/family, lost productivity, and/or societal costs in children and adolescents with musculoskeletal pain. The risk of bias was assessed with the Consolidated Health Economic Evaluation Reporting Standards checklist. All values were adjusted to the same reference year (2021) and converted to American Dollar. We included 45 cost-of-illness studies (n = 665,623). Twenty-two studies estimated the annual healthcare costs that ranged from $143 to $41,379 per patient. Nine studies estimated the annual patient/family costs that ranged from $287 to $27,972 per patient. Seven studies estimated the annual lost productivity costs that ranged from $124 to $4671 per patient. Nine studies estimated the annual societal costs that ranged from $1095 to $69,351 per patient. Children and adolescents with juvenile idiopathic arthritis and musculoskeletal pain had higher annual incremental healthcare costs than those without these conditions (mean difference: $3800 higher, 95% confidence interval [CI]: 50-7550; mean difference: $740 higher, 95% CI: 470-1,010, respectively). In conclusion, the estimated annual economic burden of children and adolescents with musculoskeletal pain ranged from $124 to $69,351.</jats:p>
2023
Hauber, Sara D.; Robinson, Katie; Kirby, Edward; Kamper, Steven; Lennox, Noirin Nealon; O'Sullivan, Kieran
In: European Journal of Pain, vol. 27, no. 4, pp. 459–475, 2023, ISSN: 1532-2149.
Abstract | Links | BibTeX | Tags: Anesthesiology and Pain Medicine, Back Pain
@article{Hauber2023,
title = {Describing the nonsurgical, nonpharmacological interventions offered to adolescents with persistent back pain in randomized trials: A scoping review},
author = {Sara D. Hauber and Katie Robinson and Edward Kirby and Steven Kamper and Noirin Nealon Lennox and Kieran O'Sullivan},
url = {https://painsmart-education.sydney.edu.au/wp-content/uploads/2024/03/Describing-the-Non-Surgical-Non-Pharmacological-Interventions-Offered-to-Adolescents-with-Persistent-Back-Pain-in-Randomized-Trials-A-Scoping-Review.pdf, PDF},
doi = {10.1002/ejp.2073},
issn = {1532-2149},
year = {2023},
date = {2023-04-00},
urldate = {2023-04-00},
journal = {European Journal of Pain},
volume = {27},
number = {4},
pages = {459--475},
publisher = {Wiley},
abstract = {<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Objectives</jats:title><jats:p>Persistent nonspecific back pain is now established as a biopsychosocial phenomenon that can be meaningfully affected by individuals' cognitions, emotions, lifestyle factors and family and social relationships. Recent guidelines for the treatment of adolescents with persistent nonspecific back pain, as well as those for youth with mixed chronic pain, strongly recommend interdisciplinary care in which adolescents receive treatment for both mind and body. The objective of this scoping review was to examine the interventions evaluated in randomized trials for adolescents with persistent back pain to determine whether they correspond to these guidelines and to reveal future research priorities.</jats:p></jats:sec><jats:sec><jats:title>Databases and data treatment</jats:title><jats:p>The review protocol was registered in March 2022. We followed the PRISMA guidelines for scoping reviews. Twelve electronic databases were searched for relevant study reports. Data were charted on study characteristics, participant characteristics and intervention details using the Template for Intervention Description and Replication (TIDieR) checklist.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The search yielded 1952 records, of which eight reports representing seven randomized trials were eligible. The most common interventions were exercise therapy (<jats:italic>n =</jats:italic> 6) and back education (<jats:italic>n</jats:italic> = 4). Five studies employed multiple intervention components, but none was multidisciplinary. Studies primarily targeted posture or biomechanical factors. One study included an intervention addressing participants' fears and beliefs about pain.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Randomized trials for adolescents with persistent back pain have primarily relied upon an outdated, biomechanical explanation of persisting pain. Future randomized trials should align with current treatment recommendations and measure outcomes across multiple biopsychosocial domains.</jats:p></jats:sec><jats:sec><jats:title>Significance</jats:title><jats:p>This scoping review describes in detail the interventions included in randomized trials for adolescents with persistent, nonspecific back pain. The review is important because it reveals discrepancies between those interventions and the interventions recommended for this population.</jats:p></jats:sec>},
keywords = {Anesthesiology and Pain Medicine, Back Pain},
pubstate = {published},
tppubtype = {article}
}
2022
Dario, Amabile Borges; Kamper, Steven James; Williams, Christopher; Straker, Leon; O’Sullivan, Peter; Schütze, Robert; Smith, Anne
Psychological distress in early childhood and the risk of adolescent spinal pain with impact Journal Article
In: European Journal of Pain, vol. 26, no. 2, pp. 522–530, 2022, ISSN: 1532-2149.
Abstract | Links | BibTeX | Tags: Anesthesiology and Pain Medicine, Back Pain
@article{Dario2021,
title = {Psychological distress in early childhood and the risk of adolescent spinal pain with impact},
author = {Amabile Borges Dario and Steven James Kamper and Christopher Williams and Leon Straker and Peter O’Sullivan and Robert Schütze and Anne Smith},
url = {https://painsmart-education.sydney.edu.au/wp-content/uploads/2024/03/Psychological-distress-in-early-childhood-and-the-risk-of-adolescent-spinal-pain-with-impact.pdf, PDF},
doi = {10.1002/ejp.1878},
issn = {1532-2149},
year = {2022},
date = {2022-02-00},
urldate = {2022-02-00},
journal = {European Journal of Pain},
volume = {26},
number = {2},
pages = {522--530},
publisher = {Wiley},
abstract = {<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Spinal pain (SP), including neck and back pain, is common and often associated with poor mental health and reduced quality of life of adolescents. Contemporary understanding of SP favours a biopsychosocial approach, and emerging evidence suggests the stronger influence of psychological rather than other factors.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>We aimed to investigate if experiencing psychological distress in early childhood increases the risk of spinal pain with impact during adolescence.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>1175 adolescents from a prospective cohort study (Raine Study Gen2) were included. Psychological distress was assessed at ages 2, 5, 8 and 10 using Child Behaviour Check List (CBCL). CBCL total and subscale scores (internalizing and externalizing symptoms) were converted to age‐standardized scores and dichotomized according to t‐scores (>60=high distress). Life‐time spinal pain, including low back, mid back, or neck/shoulder, was measured at age 17. We were interested in adolescent SP with impact (care seeking, medication use, school absenteeism, daily activity interference, leisure activity interference) and defined cases as SP with impact (one or more) or greater impact (two or more) impacts. We investigated the longitudinal associations between childhood psychological distress and adolescent SP using univariate and multivariable logistic regression models.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Psychological distress in childhood increased the odds of adolescent SP with impact by 33% (OR 1.33; 95% CI 1.01–1.76), but not spinal pain with greater impact (OR 1.22; 95% 0.83–1.80). Internalizing symptoms were associated with SP with greater impact and externalizing symptoms with SP with impact after adjusting for a range of potential child and family confounders.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Psychological distress in childhood increases the risk of SP with impact in adolescence and may be a promising prevention target.</jats:p></jats:sec><jats:sec><jats:title>Significance</jats:title><jats:p>Our findings provide evidence that psychological distress early in life is an independent risk factor for spinal pain with impact during adolescence. As psychological distress during childhood is potentially modifiable, it may be a promising target for research on the prevention of consequential spinal pain in adolescence. Identifying and addressing psychological distress in children may be an important component of best practice to reduce consequential spinal pain in adolescents.</jats:p></jats:sec>},
keywords = {Anesthesiology and Pain Medicine, Back Pain},
pubstate = {published},
tppubtype = {article}
}
2019
Leake, Hayley B.; Heathcote, Lauren C.; Simons, Laura E.; Stinson, Jennifer; Kamper, Steven J.; Williams, Christopher M.; Burgoyne, Laura L.; Craigie, Meredith; Kammers, Marjolein; Moen, David; Pate, Joshua W.; Szeto, Kimberley; Moseley, G. Lorimer
Talking to Teens about Pain: A Modified Delphi Study of Adolescent Pain Science Education Journal Article
In: Canadian Journal of Pain, vol. 3, no. 1, pp. 200–208, 2019, ISSN: 2474-0527.
Links | BibTeX | Tags: Anesthesiology and Pain Medicine, Pain
@article{Leake2019,
title = {Talking to Teens about Pain: A Modified Delphi Study of Adolescent Pain Science Education},
author = {Hayley B. Leake and Lauren C. Heathcote and Laura E. Simons and Jennifer Stinson and Steven J. Kamper and Christopher M. Williams and Laura L. Burgoyne and Meredith Craigie and Marjolein Kammers and David Moen and Joshua W. Pate and Kimberley Szeto and G. Lorimer Moseley},
url = {https://painsmart-education.sydney.edu.au/wp-content/uploads/2024/03/Talking-to-Teens-about-Pain-A-Modified-Delphi-Study-of-Adolescent-Pain-Science-Education.pdf, PDF},
doi = {10.1080/24740527.2019.1682934},
issn = {2474-0527},
year = {2019},
date = {2019-01-00},
urldate = {2019-01-00},
journal = {Canadian Journal of Pain},
volume = {3},
number = {1},
pages = {200--208},
publisher = {Informa UK Limited},
keywords = {Anesthesiology and Pain Medicine, Pain},
pubstate = {published},
tppubtype = {article}
}
Dario, Amabile B.; Kamper, Steven J.; O'Keeffe, Mary; Zadro, Joshua; Lee, Hopin; Wolfenden, Luke; Williams, Christopher M.
Family history of pain and risk of musculoskeletal pain in children and adolescents: a systematic review and meta-analysis Journal Article
In: PAIN, vol. 160, no. 11, pp. 2430–2439, 2019, ISSN: 1872-6623.
Abstract | Links | BibTeX | Tags: Anesthesiology and Pain Medicine, Neurology, Neurology (clinical), Pain
@article{Dario2019,
title = {Family history of pain and risk of musculoskeletal pain in children and adolescents: a systematic review and meta-analysis},
author = {Amabile B. Dario and Steven J. Kamper and Mary O'Keeffe and Joshua Zadro and Hopin Lee and Luke Wolfenden and Christopher M. Williams},
url = {https://painsmart-education.sydney.edu.au/wp-content/uploads/2024/03/Family-history-of-pain-and-risk-of-musculoskeletal-pain_-a-systematic-review.pdf, PDF},
doi = {10.1097/j.pain.0000000000001639},
issn = {1872-6623},
year = {2019},
date = {2019-00-00},
urldate = {2019-00-00},
journal = {PAIN},
volume = {160},
number = {11},
pages = {2430--2439},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
abstract = {<jats:title>Abstract</jats:title>
<jats:p>Emerging evidence suggests that musculoskeletal (MSK) pain should be viewed from a biopsychosocial perspective and consider the influence of family factors. We conducted a review with meta-analysis to provide summary estimates of effect of family history of pain on childhood MSK pain and explore whether specific family pain factors influence the strength of the association (PROSPERO CRD42018090130). Included studies reported associations between family history of pain and nonspecific MSK pain in children (age <19 years). The outcome of interest was MSK pain in children. We assessed the methodological quality using a modified version of the Quality in Prognosis Studies instrument and quality of evidence for the main analyses using the GRADE criteria. After screening of 7281 titles, 6 longitudinal and 23 cross-sectional studies were included. Moderate quality evidence from 5 longitudinal studies (n = 42,131) showed that children with a family history of MSK pain had 58% increased odds of experiencing MSK pain themselves (odds ratio [OR] 1.58, 95% confidence interval 1.20-2.09). Moderate quality evidence from 18 cross-sectional studies (n = 17,274) supported this finding (OR 2.02, 95% 1.69-2.42). Subgroup analyses showed that the relationship was robust regardless of whether a child's mother, father, or sibling experienced pain. Odds were higher when both parents reported pain compared with one ([mother OR = 1.61; father OR = 1.59]; both parents OR = 2.0). Our findings show moderate quality evidence that children with a family history of pain are at higher risk of experiencing MSK pain. Understanding the mechanism by which this occurs would inform prevention and treatment efforts.</jats:p>},
keywords = {Anesthesiology and Pain Medicine, Neurology, Neurology (clinical), Pain},
pubstate = {published},
tppubtype = {article}
}
<jats:p>Emerging evidence suggests that musculoskeletal (MSK) pain should be viewed from a biopsychosocial perspective and consider the influence of family factors. We conducted a review with meta-analysis to provide summary estimates of effect of family history of pain on childhood MSK pain and explore whether specific family pain factors influence the strength of the association (PROSPERO CRD42018090130). Included studies reported associations between family history of pain and nonspecific MSK pain in children (age <19 years). The outcome of interest was MSK pain in children. We assessed the methodological quality using a modified version of the Quality in Prognosis Studies instrument and quality of evidence for the main analyses using the GRADE criteria. After screening of 7281 titles, 6 longitudinal and 23 cross-sectional studies were included. Moderate quality evidence from 5 longitudinal studies (n = 42,131) showed that children with a family history of MSK pain had 58% increased odds of experiencing MSK pain themselves (odds ratio [OR] 1.58, 95% confidence interval 1.20-2.09). Moderate quality evidence from 18 cross-sectional studies (n = 17,274) supported this finding (OR 2.02, 95% 1.69-2.42). Subgroup analyses showed that the relationship was robust regardless of whether a child's mother, father, or sibling experienced pain. Odds were higher when both parents reported pain compared with one ([mother OR = 1.61; father OR = 1.59]; both parents OR = 2.0). Our findings show moderate quality evidence that children with a family history of pain are at higher risk of experiencing MSK pain. Understanding the mechanism by which this occurs would inform prevention and treatment efforts.</jats:p>
2015
Swain, Michael Steven; Henschke, Nicholas; Kamper, Steven James; Gobina, Inese; Ottová-Jordan, Veronika; Maher, Christopher Gerard
Pain and Moderate to Vigorous Physical Activity in Adolescence: An International Population-Based Survey Journal Article
In: Pain Med, pp. n/a–n/a, 2015, ISSN: 1526-2375.
Links | BibTeX | Tags: Anesthesiology and Pain Medicine, General Medicine, Neurology (clinical), Pain
@article{Swain2015,
title = {Pain and Moderate to Vigorous Physical Activity in Adolescence: An International Population-Based Survey},
author = {Michael Steven Swain and Nicholas Henschke and Steven James Kamper and Inese Gobina and Veronika Ottová-Jordan and Christopher Gerard Maher},
url = {https://painsmart-education.sydney.edu.au/wp-content/uploads/2024/03/Pain-and-Moderate-to-Vigorous-Physical-Activity-in-Adolescence-An-International-Population-Based-Survey.pdf, PDF},
doi = {10.1111/pme.12923},
issn = {1526-2375},
year = {2015},
date = {2015-09-00},
urldate = {2015-09-00},
journal = {Pain Med},
pages = {n/a--n/a},
publisher = {Oxford University Press (OUP)},
keywords = {Anesthesiology and Pain Medicine, General Medicine, Neurology (clinical), Pain},
pubstate = {published},
tppubtype = {article}
}